Trending @Accenture; Seeking everyones advice

Hi ,I am having 5+ years of experience in fullstack role. But from starting day to til I am working in remote mode.but my organisation forced to come and visit the office.but my family uncertaintys I won't be able to go to office. My thought would be like resign from the company and in the period of notice time would be search the job,but in my hand no other offer exsist.

My question is to everyone is Is it better to resign now with out any offer or else which month would be better to resign and get more interview calls?

Please need your suggestions.