I have resigned but my supervisor has not accepted it yet from past 2 weeks will it cause any issue?

Where status of resignation can be checked in ultimatix?

If your resignation isn't accepted in 2 weeks, escalate to higher management and HR. Document all communications. Your notice period should start from your resignation email date.

Keep sending alternate day remainder to HR and Manager

Just chill your resignation starts when you drop the email you have already spent 14 days of your NP.