Yes, some professionals have cracked remote US roles from India, but it's tough. Most US companies require you to be legally eligible to work there (citizen/green card/H1B). However, a few options exist:
Global remote-first companies (e.g., GitLab, Automattic) sometimes hire internationally.
Contract roles via platforms like Toptal or Upwork can bypass location barriers.
Indian product firms serving US clients (e.g., SaaS startups) may offer similar exposure.
Workaround: Target companies with Indian subsidiaries (e.g., Salesforce, Microsoft) for roles that collaborate with US teams.
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