It depends on the scale of the startup. If you want to start a business and scale it slowly in your own time then boostrap - you can decide your balance and own your time.
If you are looking to scale it fast and run it on VC fuel, then frankly, even my cat is not happy with me :). But then there are many successful married female founders; but mostly they are building with their life partner etc.
I hope you find a way to take the plunge. Personally, I feel buildinf a startup is the most fun anyone can have; even on most excruciating days